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It shifts melanin synthesis toward a lighter pigment called pheomelanin rather than the darker eumelanin, which is why many people notice a gradual brightening or evening of skin tone with consistent use

The compound showed an in vitro NNMT IC 50 of approximately 1.2 M and did not inhibit related methyltransferases at concentrations tested

Colon Cancer - Oral curcumin in advanced colorectal cancer patients refractory to standard chemotherapies resulted in stable disease for 2-4 months in five of fifteen patients